Peculiarities of meroterpenoids and their bioproduction

Meroterpenoids are a class of terpenoid-containing hybrid natural products with impressive structural architectures and remarkable pharmacological activities. Remarkable advances in enzymology synthetic biology have greatly contributed to the elucidation molecular basis for their biosynthesis. Here, we review structurally unique meroterpenoids catalyzed by novel enzymes unusual enzymatic reactions over period last 5 years. We also discuss recent progress on biomimetic synthesis chrome biology-driven biomanufacturing tropolone sesquiterpenoids, merochlorins, plant-derived meroterpenoid cannabinoids. In particular, focus involved biosynthesis polyketide-terpenoids, nonribosomal peptide-terpenoids, terpenoid alkaloids, structures. The biological activities these discussed. information reviewed here might provide useful clues lay foundation developing new meroterpenoid-derived drugs. • possess intriguing features relevant Novel Biomimetic enable construction manufacturing complex meroterpenoids.